Reaction state_transition d_re517 map

gIntact_DNA*@Nucleus map → gGG-NER_DNA_st1*@Nucleus map

Reaction regulators:
Catalysis
  1. UV@Nucleus map
  2. ROS@Nucleus map
  3. Interstrand crosslinking agents*@Nucleus map
  4. Alkylating agents*@Nucleus map
  5. Lipid peroxides*@Nucleus map


References
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
Interstrand crosslinking agents induce NER
PMID:21701511
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366

Confidence
REF=4 FUNC=5