Gene GG-NER_DNA_st1* map

Identifiers
GG-NER:DNA:st1
Transcriptionally silent chemically or stracturally modyfied DNA
Damage types are bulky adducts, 6-4 phosphoproducts, cyclobutane, pyrimidine dimer, methylated bases caused by UV light, hydrocarbons, alkylators
Node_Type:Generic

Maps_Modules
 dnarepair  map

References
PMID:23892398
PMID:20211143, PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366

gGG-NER_DNA_st1*@Nucleus

References
d_re517( dnarepair  map ):
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
Interstrand crosslinking agents induce NER
PMID:21701511
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366
d_re569:( dnarepair  map ) reactionType:is.a
d_re252( dnarepair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011
Link between Fanconi and NER
PMID:22615860
d_re254( dnarepair  map ):
GADD45 interacts with PCNA and activates NER-only Global(GG-NER):
PMID:19652693, PMID:10779360

Modifications:
In compartment: Nucleus
  1. gGG-NER_DNA_st1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gGG-NER_DNA_st1*@Nucleus map → map gDamaged_DNA*@Nucleus map
    2. gGG-NER_DNA_st1*@Nucleus map → map gGG-NER_DNA_st2*@Nucleus map
    3. gIntact_DNA*@Nucleus map → map gGG-NER_DNA_st1*@Nucleus map
    4. gBbulky_adducts*@Nucleus map → map gGG-NER_DNA_st1*@Nucleus map
    5. gPyrimidine_dimer*@Nucleus map → map gGG-NER_DNA_st1*@Nucleus map
    6. g6-4_phosphoproducts*@Nucleus map → map gGG-NER_DNA_st1*@Nucleus map
    As Catalyser:
    1. GADD45A@default map + PCNA@default map → map GADD45A:​PCNA@Nucleus map
    2. CDK1:​CyclinB1*@default map + GADD45A@default map → map CDK1:​CyclinB1*:​GADD45A@default map