Identifiers
heat shock protein 90kDa alpha (cytosolic), class B member
HUGO:HSPC2 GENECARDS:HSPC2 KEGG:3326 WIKI:HSPC2 HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1
Maps_Modules
apoptosis
dnarepair
dnarepair
dnarepair
cellcycle
survival
References
PMID:22869732, PMID:17327415
References
d_re120( dnarepair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re523( dnarepair ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732
d_re525( dnarepair ):
HSP90 redirects FANCA to degradation, inhibits Fanconi pathway and increases sensitivity to cross-linking agents
PMID:17327415