Identifiers
breast cancer 1, early onset
HUGO:BRCA1 HGNC:1100 ENTREZ:672 UNIPROT:P38398 GENECARDS:BRCA1 REACTOME:50950 KEGG:672 ATLASONC:BRCA1ID163ch17q21 WIKI:BRCA1

Maps_Modules
 apoptosis 
 dnarepair 
 dnarepair 
 dnarepair 
 dnarepair 
 dnarepair 

References
For S-phase checkpoint
PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331

References
d_re523( dnarepair  ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732

References
d_re33:( dnarepair  ) PMID:15485915
d_re34:( dnarepair  ) PMID:19788416
d_re48( dnarepair  ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474
d_re118( dnarepair  ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
d_re121( dnarepair  ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915
d_re166( dnarepair  ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
d_re204:( dnarepair  ) PMID:15242590
d_re226( dnarepair  ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961
d_re228( dnarepair  ):
BRCA1 enhances transcription of DDB2 in p53 independent manner
PMID:19004803, PMID:12496474, PMID:12170778
p53 enhances transcription of DDB2:
d_re231( dnarepair  ):
BRCA1 upregulates transcription of XPC in p53 independed manner:
p53 enhances transcription of XPC:
d_re344:( dnarepair  ) CHECKPOINT is p53_dependent_G1S_checkpoint

References
d_re523( dnarepair  ):
HSP90 redirects BRCA1 to degradation, inhibits HR and G2/M chechpoint, increases sensitivity to cross-linking agents
PMID:22869732

1. BRCA1@default
2. BRCA1|​ubi@default
3. BRCA1|​S308_pho@default
4. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default

1. BARD1:​BRCA1@default
2. AURKA:​BRCA1|​S308_pho@default
3. BRCA1:​SMC1*|​S957_pho@default
4. BRCA1:​SMC3|​S1083_pho@default
5. BRCA1:​FANCJ*|​S990_pho@default
6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default
7. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default
8. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default
9. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default
10. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default
11. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
12. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
13. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default

1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default + MRE11*:​NBS1*|​S343_pho:​RAD50@default + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default → BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default
2. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default
3. BARD1@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default → BARD1:​BRCA1@default
4. RAD51:​XRCC2:​XRCC3@default + BARD1:​BRCA1@default + RAD52@default + BRCA2:​DSS1*@default + FANCN*@default + FANCD2|​K561_ubi|​pho@default + BRIT1*@default + SFPQ@default → BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default
5. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default + BRCA2@default + NBS1*|​S343_pho@default + RAD51@default + PCNA@default + H2AFX|​S139_pho|​ubi@default + TIP60*@default → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
6. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default + BRCA2@default + FANCJ*@default + RPA1:​RPA2:​RPA3@default + FANCN*@default + FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default → BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default
7. FANCJ*|​S990_pho@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default → BRCA1:​FANCJ*|​S990_pho@default
8. rBRCA1@default → BRCA1@default
9. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​S139_pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default
10. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default → BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default
11. BRCA1@default → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default
12. E2F1:​RB1@default + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default → BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default
13. BRCA1@default → BRCA1|​S308_pho@default
14. BRCA1|​S308_pho@default + AURKA@default → AURKA:​BRCA1|​S308_pho@default
15. BRCA1@default + SMC1*|​S957_pho|​S966_pho@default → BRCA1:​SMC1*|​S957_pho@default
16. SMC3|​S1083_pho@default + BRCA1@default → BRCA1:​SMC3|​S1083_pho@default
17. BRCA1@default → BRCA1|​ubi@default
18. BRCA1|​ubi@default → degraded

1. gHR_DNA_st1*@Nucleus → gHR_DNA_st2*@Nucleus
2. G1 phase@default → S phase@default
3. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default → CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default
4. G2 phase@default → M phase@default
5. gHR_DNA_st2*@Nucleus → gHR_DNA_st3*@Nucleus
6. gHR_DNA_st3*@Nucleus → gHR_DNA_st4*@Nucleus
7. gFanconi_DNA_st4*@Nucleus → gFanconi_DNA_st5*@Nucleus
8. gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus
9. gGADD45*@default → rGADD45*@default
10. gDDB2@default → rDDB2@default
11. gXPC@default → rXPC@default
12. CHEK1@default → CHEK1|​pho|​active@default
13. p53*@default → p53*|​pho|​ace|​active@default
14. gCIP/KIP*@default → rCIP/KIP*@default
15. gMAD2*@default → rMAD2*@default
16. gBUB1@default → rBUB1@default
17. No DNA replicarion@default → DNA replicarion@default
18. p53*@default → degraded
19. gC_NHEJ_DNA_st1*@Nucleus → gC_NHEJ_DNA_st2*@Nucleus