Gene TLS_DNA_st2* map

Identifiers
TLS:DNA:st2
Repaired DNA
Node_Type:Generic

Maps_Modules
 dnarepair  map

References
For actovation of TLS by cross-linking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263

gTLS_DNA_st2*@Nucleus

References
d_re489( dnarepair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823
d_re509:( dnarepair  map ) reactionType:is.a

Modifications:
In compartment: Nucleus
  1. gTLS_DNA_st2*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTLS_DNA_st1*@Nucleus map → map gTLS_DNA_st2*@Nucleus map
    2. gTLS_DNA_st2*@Nucleus map → map gRepaired_DNA*@Nucleus map
    As Catalyser: