Reaction state_transition re66 map

STAT1@Cytoplasm map → STAT1|​pho@Cytoplasm map

Reaction regulators:
Catalysis
  1. JAK1|​pho@Cytoplasm map
  2. TYK2|​pho@Cytoplasm map
  3. JAK2|​pho@Cytoplasm map
Unknown_inhibition
  1. SOCS3@Cytoplasm map





PMID:9857039 Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998 Dec 25;273(52):35056-62.
PMID:11577084 Woldman I, Varinou L, Ramsauer K, Rapp B, Decker T. The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. J Biol Chem. 2001 Dec 7;276(49):45722-8.
PMID:11325598. David E. Levy and Adolfo Garcia­Sastre. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine & Growth Factor Reviews Volume 12, Issues 2-3 , June 2001, Pages 143-156
PMID:9933596.Owen W. Nadeauab, Paul Domanskiab, Anna Usachevaac, Shahab Uddind, Leonidas C. Plataniasd, Paula Pithae, Regina Razf, David Levyf, Beata Majchrzakg, Eleanor Fishg, and Oscar R. Colamonici. The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation.J Biol Chem, Vol. 274, Issue 7, 4045-4052, February 12, 1999
PMID:8232552. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al.The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993 Nov 11;366(6451):129-35.
PMID:11821064 Komatsu T, Takeuchi K, Yokoo J, Gotoh B.Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1.FEBS Lett. 2002 Jan 30;511(1-3):139-44.
PMID:12804771.Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K.Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.FEBS Lett. 2003 Jun 19;545(2-3):177-82.