Reaction state_transition re100 map

Uev1A@Cytoplasm map + UBC13@Cytoplasm map + Ubiquitin@Cytoplasm map + (TAB1:​TAB2:​TAK1 |​pho:​TRAF6)|​active@Cytoplasm map → TRAF6|​ubi|​active@Cytoplasm map

No reaction regulators




PMID:15258597. Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Nature. 2004 Aug 5;430(7000):694-9. Epub 2004 Jul 18.
PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)
PMID:10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000)
PMID:11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).