Reaction state_transition re103 map

TAB1:​TAB2|​pho:​TAK1 |​pho:​TRAF6@Cytoplasm map → TAK1 |​pho|​active@Cytoplasm map

No reaction regulators




PMID:10882101. Takaesu, G. et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5, 649-658 (2000)
PMID:11057907.Deng, L. et al. Activation of the IkappaB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
PMID:11460167. Chen Wang1,2, Li Deng1,2, Mei Hong1, Giridhar R. Akkaraju1, Jun-ichiro Inoue3 and Zhijian J. Chen. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (19 July 2001)
PMID:15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67.
PMID:11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.
PMID:15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8.