Reaction state_transition re104 map

IRF3@Cytoplasm map → IRF3|​pho|​hm2@Cytoplasm map

Reaction regulators:
Catalysis
  1. IKKE:​NAP1:​TBK1@Cytoplasm map
  2. (IKKE:​TANK:​TBK1)|​active@Cytoplasm map
Unknown_catalysis
  1. AKT|​pho@Cytoplasm map





PMID:14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93.
PMID:15367631. tenOever BR,Sharma S, Zou W, Sun Q, Grandvaux N,Julkunen I,Hemmi H,Yamamoto M,Akira S,Yeh WC, Lin R,Hiscott J. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol. 2004 Oct;78(19):10636-49.
PMID:16699525. Tatsuya Saitoh1, Adrian Tun-Kyi, Akihide Ryo, Masahiro Yamamoto, Greg Finn, Takashi Fujita, Shizuo Akira, Naoki Yamamoto1, Kun Ping Lu & Shoji Yamaoka. Negative regulation of interferon-regulatory factor 3–dependent innate antiviral response by the prolyl isomerase Pin1. Nature Immunology 7, 598 - 605 (2006)
PMID:15502848.Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.Nat Struct Mol Biol. 2004 Nov;11(11):1060-7.
PMID:16474426; Seth, R. B., Sun, L. & Chen, Z. J. Antiviral innate immunity pathways. Cell Res 16, 141-7 (2006).
PMID:16452304; Sasai, M., Matsumoto, M. & Seya, T. The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC). J Biochem (Tokyo) 139, 171-5 (2006).
PMID:16309964; Johnson, C. L. & Gale, M., Jr. CARD games between virus and host get a new player. Trends Immunol 27, 1-4 (2006).
[Formation of IKKE-complex]
PMID:12692549; Fitzgerald, K. A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4, 491-6 (2003).
PMID:16452304; Sasai, M., Matsumoto, M. & Seya, T. The Kinase Complex Responsible for IRF-3-Mediated IFN-{beta} Production in Myeloid Dendritic Cells (mDC). J Biochem (Tokyo) 139, 171-5 (2006).
PMID:16125763. Seth RB, Sun L, Ea CK, Chen ZJ.Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005 Sep 9;122(5):669-82.
PMID:14679297. McWhirter, S. M.; Fitzgerald, K. A.; Rosains, J.; Rowe, D. C.; Golenbock, D. T.; Maniatis, T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Nat. Acad. Sci. 101: 233-238, 2004.
PMID:16125763. Seth RB, Sun L, Ea CK, Chen ZJ.Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005 Sep 9;122(5):669-82.