Reaction state_transition re106 map

TRAF3@Endosome map → IKKE:​NAP1:​TBK1@Cytoplasm map

Reaction regulators:
Inhibition
  1. SIKE@Cytoplasm map





PMID:17327220; Beichu Guo and Genhong ChengModulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK. J. Biol. Chem., Vol. 282, Issue 16, 11817-11826, April 20, 2007
PMID:14560022.Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93.
PMID:16281057. Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J. 2005 Dec 7;24(23):4018-28. Epub 2005 Nov 10.
PMID:12539043. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.Nat Immunol. 2003 Feb;4(2):161-7. Epub 2003 Jan 21.
PMID:12471095. Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S. A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.Nat Immunol. 2003 Feb;4(2):105-6
PMID:14530355.Sato S,Sugiyama M,Yamamoto M,Watanabe Y,Kawai T,Takeda K,Akira S.Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.J Immunol. 2003 Oct 15;171(8):4304-10