Protein SIKE map
SIKE@Cytoplasm
GeneID:80143
Notes:SIKE is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation.It is a suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF-3 but not NF-kappaB activation pathways.
Modifications:
In compartment: Cytoplasm
  1. SIKE@Cytoplasm map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CASP8_CLEAVED@Cytoplasm map → map SIKE@Cytoplasm map
    As Catalyser:
    1. TRAF3@Endosome map → map IKKE:​NAP1:​TBK1@Cytoplasm map
    2. TBK1@Cytoplasm map + IKK1@Cytoplasm map + NAP1@Cytoplasm map → map IKKE:​NAP1:​TBK1@Cytoplasm map