Reaction state_transition re164
TLR4@Cytoplasm
+ TIRAP@Cytoplasm
+ MYD88@Cytoplasm
+ MD2@Cytoplasm
→ MD2:MYD88:TIRAP:TLR4@Cytoplasm
Reaction regulators:
- Catalysis
- LPS@default
PMID:15596121.Fitzgerald KA, Rowe DC, Golenbock DT.Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec;6(15):1361-7.
PMID:12447441.Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-9.
PMID:9734363. Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA Jr. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. 1998 Aug;2(2):253-8.
PMID:11976338.Re F, Strominger JL. Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness.J Biol Chem. 2002 Jun 28;277(26):23427-32. Epub 2002 Apr 25.
PMID:15485931.Beinke S, Robinson MJ, Hugunin M, Ley SC.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol. 2004 Nov;24(21):9658-67.
PMID:11297557. Salmeron A, Janzen J, Soneji Y, Bump N, Kamens J, Allen H, Ley SC.Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.J Biol Chem. 2001 Jun 22;276(25):22215-22. Epub 2001 Apr 10.
PMID:15199157. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC.IkappaB kinase is an essential component of the Tpl2 signaling pathway.Mol Cell Biol. 2004 Jul;24(13):6040-8.