Protein TLR4 map
The Molecular Pattern receptor Toll-like Receptor 4 is involved in recognition of Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria and is a component of the bacterial cell wall. It is a potent activator of the innate immune response in humans. In macrophages, lipid A (a form of LPS) activation of TLR4 triggers the biosynthesis of diverse mediators of inflammation, for eg TNF-alpha and IL1-beta, and activates the production of costimulatory molecules required for the adaptive immune response.
TLR4@Cytoplasm
GeneID:7099
TLR4@Cytoplasm
GeneID:7099
Modifications:
In compartment: Cytoplasm
  1. TLR4@Cytoplasm map
  2. TLR4@Cytoplasm map
Participates in complexes:
In compartment: Cytoplasm
  1. MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map
  2. MD2:​TICAM-2:​TLR4:​TRIF@Cytoplasm map
  3. MD2:​RIP1:​TICAM-2:​TLR4:​TRIF@Cytoplasm map
  4. IRAK1:​IRAK4:​MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. TLR4@Cytoplasm map + TIRAP@Cytoplasm map + MYD88@Cytoplasm map + MD2@Cytoplasm map → map MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map
  2. MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map + IRAK4@Cytoplasm map + IRAK1@Cytoplasm map → map IRAK1:​IRAK4:​MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map
  3. IRAK1:​IRAK4:​MD2:​MYD88:​TIRAP:​TLR4@Cytoplasm map → map IRAK1|​pho|​pho|​pho@Cytoplasm map
  4. MD2:​TICAM-2:​TLR4:​TRIF@Cytoplasm map + RIP1@Cytoplasm map → map MD2:​RIP1:​TICAM-2:​TLR4:​TRIF@Cytoplasm map
  5. MD2:​RIP1:​TICAM-2:​TLR4:​TRIF@Cytoplasm map → map IKKE:​NAP1:​TBK1@Cytoplasm map
  6. TLR4@Cytoplasm map + TRIF@Cytoplasm map + TICAM-2@Cytoplasm map + MD2@Cytoplasm map → map MD2:​TICAM-2:​TLR4:​TRIF@Cytoplasm map
  7. LPS@default map → map TLR4@Cytoplasm map
As Catalyser: