Reaction state_transition re197 map

IRF3|​pho|​hm2@Cytoplasm map → IRF3|​ubi|​hm2@Cytoplasm map

Reaction regulators:
Catalysis
  1. PIN1@Cytoplasm map





Pin1 is involved in the termination of IRF3-dependent transcriptional activation.Pin1 interacts with IRF3 through its phosphorylated Ser339–Pro340 and promotes proteasome-dependent degradation of activated IRF3.
PMID:16699525.Saitoh T,Tun-Kyi A,Ryo A,Yamamoto M, Finn G,Fujita T,Akira S,Yamamoto N, Lu KP,Yamaoka S.Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.Nat Immunol. 2006 Jun;7(6):555-7.