Protein p27

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Modifications:
In compartment: Cell membrane

1. p27|​S10_pho@Cell membrane
2. p27|​S10_pho|​ubi@Cell membrane
3. p27|​S10_pho|​T198_pho@Cell membrane
4. p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane

In compartment: Nucleus

1. p27@Nucleus
2. p27|​S10_pho@Nucleus
3. p27|​Y88_pho|​Y74_pho@Nucleus
4. p27|​T187_pho|​Y88_pho|​Y74_pho@Nucleus
5. p27|​T187_pho|​Y88_pho|​Y74_pho|​ubi@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. CRM1:​p27|​S10_pho@Cell membrane
2. CDK4/6:​Cyclin D:​p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane
3. CDK4/6:​Cyclin D:​p27|​S10_pho|​Y88_pho|​Y74_pho|​T198_pho|​T157_pho@Cell membrane

In compartment: Nucleus

1. CRM1:​p27|​S10_pho@Nucleus
2. CDK2:​Cyclin E:​p27@Nucleus
3. CDK2:​Cyclin E:​p27|​S10_pho@Nucleus
4. CDK2:​Cyclin E:​p27|​Y88_pho|​Y74_pho@Nucleus

Participates in reactions:
As Reactant or Product:

1. CDK2:​Cyclin E@Nucleus + p27@Nucleus → CDK2:​Cyclin E:​p27@Nucleus
2. CDK2:​Cyclin E:​p27@Nucleus → CDK2:​Cyclin E:​p27|​S10_pho@Nucleus
3. CRM1:​p27|​S10_pho@Nucleus → CRM1:​p27|​S10_pho@Cell membrane
4. p27|​S10_pho@Nucleus + CRM1@Nucleus → CRM1:​p27|​S10_pho@Nucleus
5. CRM1:​p27|​S10_pho@Cell membrane → CRM1@Cell membrane + p27|​S10_pho@Cell membrane
6. p27|​S10_pho@Cell membrane → p27|​S10_pho|​ubi@Cell membrane
7. p27|​S10_pho|​ubi@Cell membrane → degraded
8. CDK2:​Cyclin E:​p27@Nucleus → CDK2:​Cyclin E:​p27|​Y88_pho|​Y74_pho@Nucleus
9. CDK2:​Cyclin E:​p27|​S10_pho@Nucleus → CDK2:​Cyclin E@Nucleus + p27|​S10_pho@Nucleus
10. CDK2:​Cyclin E:​p27|​Y88_pho|​Y74_pho@Nucleus → p27|​Y88_pho|​Y74_pho@Nucleus + CDK2:​Cyclin E@Nucleus
11. p27|​Y88_pho|​Y74_pho@Nucleus → p27|​T187_pho|​Y88_pho|​Y74_pho@Nucleus
12. p27|​T187_pho|​Y88_pho|​Y74_pho@Nucleus → p27|​T187_pho|​Y88_pho|​Y74_pho|​ubi@Nucleus
13. p27|​T187_pho|​Y88_pho|​Y74_pho|​ubi@Nucleus → degraded
14. p27|​S10_pho@Cell membrane → p27|​S10_pho|​T198_pho@Cell membrane
15. CDK4/6@Cell membrane + Cyclin D@Cell membrane → CDK4/6:​Cyclin D:​p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane
16. p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane + Cyclin D@Cell membrane → CDK4/6:​Cyclin D:​p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane
17. p27|​S10_pho@Cell membrane → p27|​S10_pho@Cell membrane
18. p27|​S10_pho@Cell membrane → p27@Nucleus
19. p27|​S10_pho|​T198_pho@Cell membrane → p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane
20. CDK4/6:​Cyclin D:​p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane → CDK4/6:​Cyclin D:​p27|​S10_pho|​Y88_pho|​Y74_pho|​T198_pho|​T157_pho@Cell membrane

As Catalyser:

1. p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane + Cyclin D@Cell membrane → CDK4/6:​Cyclin D:​p27|​S10_pho|​T198_pho|​T157_pho@Cell membrane
2. p27|​S10_pho@Cell membrane → p27@Nucleus