Protein BAD
Phosphorylation of BAD at any of these three sites (S112, S155, S136)results in its association with 14-3-3 protein
in the cytosol, thereby freeing BCL-2 and BCL-Xl to promote cell survival
Modifications:
In compartment: Mitochondria
- BAD@Mitochondria
- BAD|S136_pho@Mitochondria
Participates in complexes:
In compartment: Cell membrane
- 14-3-3:BAD|S136_pho@Cell membrane
Participates in reactions:
As Reactant or Product:- BAD@Mitochondria
→
BAD|S136_pho@Mitochondria
- BAD|S136_pho@Mitochondria
+ 14-3-3@Cell membrane
→
14-3-3:BAD|S136_pho@Cell membrane
- 14-3-3:BAD|S136_pho@Cell membrane
→
Cell survival@Cell membrane
- BAD@Mitochondria
→
Apoptosis@Mitochondria
As Catalyser: