Reaction dissociation re331 map

14-3-3:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane map → TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane map + 14-3-3@Cell membrane map

Reaction regulators:
Catalysis
  1. 14-3-3:​REDD1@Cell membrane map





PMID:18198340
In response to hypoxia, REDD1 is induced and binds 14-3-3, resulting in TSC2/14-3-3 dissociation, TSC1/2 activation, and mTORC1 inhibition.