Protein TSC2

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Modifications:
In compartment: Cell membrane

1. TSC2@Cell membrane
2. TSC2|​ubi@Cell membrane
3. TSC2|​S664_pho@Cell membrane
4. TSC2|​S1210_pho@Cell membrane
5. TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane
6. TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane
7. TSC2|​S981_pho|​S939_pho|​S1798_pho|​T1462_pho@Cell membrane

In compartment: Nucleus

1. TSC2|​S1798_pho@Nucleus

Participates in complexes:
In compartment: Cell membrane

1. 14-3-3:​TSC2|​S1210_pho@Cell membrane
2. 14-3-3:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane
3. Dishevelled:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane

In compartment: Centrosome

1. TSC1|​T310_pho:​TSC2@Centrosome
2. Plk1:​TSC1|​T310_pho:​TSC2@Centrosome

In compartment: Endomembrane

1. TSC1:​TSC2@Endomembrane
2. TSC1:​TSC2@Endomembrane
3. TSC1:​TSC2|​S664_pho@Endomembrane
4. TSC1|​T310_pho:​TSC2@Endomembrane
5. TSC1:​TSC2|​S1345_pho@Endomembrane
6. TSC1:​TSC2|​S1798_pho@Endomembrane
7. TSC1|​T357_pho|​T390_pho:​TSC2@Endomembrane
8. TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane
9. TSC1|​T417_pho|​S584_pho|​T1047_pho:​TSC2@Endomembrane
10. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
11. TBC7:​TSC1:​TSC2@Endomembrane
12. FIP200:​TSC1:​TSC2@Endomembrane
13. TBC7:​TSC1|​ubi:​TSC2@Endomembrane
14. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane
15. IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane
16. GADD34:​TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane
17. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
18. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
19. Rictor:​Sin1.1:​TSC1:​TSC2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Endomembrane

Participates in reactions:
As Reactant or Product:

1. TSC1:​TSC2@Endomembrane → TSC1|​T357_pho|​T390_pho:​TSC2@Endomembrane
2. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S1798_pho@Endomembrane
3. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S664_pho@Endomembrane
4. TSC2@Cell membrane → TSC2|​S1798_pho@Nucleus
5. TSC2|​S1798_pho@Nucleus → ER_alpha-mediated_br_transcription@Nucleus
6. TSC2|​S1798_pho@Nucleus → TSC2|​S981_pho|​S939_pho|​S1798_pho|​T1462_pho@Cell membrane
7. TSC1:​TSC2|​S1345_pho@Endomembrane → TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
8. 14-3-3@Cell membrane + TSC2|​S1210_pho@Cell membrane → 14-3-3:​TSC2|​S1210_pho@Cell membrane
9. TSC2@Cell membrane → TSC2|​S1210_pho@Cell membrane
10. 14-3-3:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane → TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane + 14-3-3@Cell membrane
11. TSC1@Cell membrane + TSC2@Cell membrane → TSC1:​TSC2@Endomembrane
12. TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane → TSC2@Cell membrane
13. TSC2@Cell membrane → TSC2|​ubi@Cell membrane
14. TSC2|​ubi@Cell membrane → degraded
15. TSC2@Cell membrane → TSC2|​ubi@Cell membrane
16. TSC1:​TSC2@Endomembrane → TSC1|​T417_pho|​S584_pho|​T1047_pho:​TSC2@Endomembrane
17. TSC1:​TSC2|​S664_pho@Endomembrane → TSC1@Endomembrane + TSC2|​S664_pho@Cell membrane
18. TSC1:​TSC2@Endomembrane → TSC1|​T310_pho:​TSC2@Endomembrane
19. TSC1:​TSC2@Endomembrane + FIP200@Cell membrane → FIP200:​TSC1:​TSC2@Endomembrane
20. TBC7:​TSC1:​TSC2@Endomembrane → TBC7:​TSC1|​ubi:​TSC2@Endomembrane
21. TBC7:​TSC1|​ubi:​TSC2@Endomembrane → degraded
22. TBC7@Cell membrane + TSC1:​TSC2@Endomembrane → TBC7:​TSC1:​TSC2@Endomembrane
23. TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane → TSC1:​TSC2@Endomembrane
24. GADD34@Cell membrane + TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane → GADD34:​TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane
25. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane
26. TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane → TSC1@Endomembrane + TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane
27. TSC1:​TSC2|​S1345_pho@Endomembrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane
28. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
29. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC1@Endomembrane + TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane
30. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane → TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane + Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta@Cell membrane
31. TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane + Dishevelled@Cell membrane → Dishevelled:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Cell membrane
32. 14-3-3@Cell membrane + TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane → 14-3-3:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane
33. 14-3-3:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Cell membrane → degraded
34. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane
35. IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho@Endomembrane + TSC2@Cell membrane
36. IKK_beta|​pho|​active@Cell membrane + TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1:​TSC2@Endomembrane
37. TSC2@Cell membrane → VEGF, tumor angiogenesis@Cell membrane
38. Plk1@Centrosome + TSC1|​T310_pho:​TSC2@Centrosome → Plk1:​TSC1|​T310_pho:​TSC2@Centrosome
39. TSC1|​T310_pho:​TSC2@Endomembrane → TSC1|​T310_pho:​TSC2@Centrosome
40. TSC1:​TSC2@Endomembrane + Rictor:​Sin1.1:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Cell membrane → Rictor:​Sin1.1:​TSC1:​TSC2:​mLST8:​mTOR|​S2481_pho|​S1261_pho@Endomembrane
41. TSC1:​TSC2@Endomembrane → TSC1:​TSC2|​S1345_pho@Endomembrane
42. rTsc2@Nucleus → TSC2@Cell membrane

As Catalyser:

1. GTP:​Rheb@Rab7 vesicular structure → GDP:​Rheb@Rab7 vesicular structure
2. TSC1@Cell membrane + TSC2@Cell membrane → TSC1:​TSC2@Endomembrane
3. GTP:​Rheb@Rab7 vesicular structure → GDP:​Rheb@Rab7 vesicular structure
4. TSC1:​TSC2|​S981_pho|​S939_pho|​T1462_pho@Endomembrane → TSC1:​TSC2@Endomembrane
5. GTP:​Rheb@Rab7 vesicular structure + GDP@Rab7 vesicular structure → GDP:​Rheb@Rab7 vesicular structure + GTP@Rab7 vesicular structure
6. Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho@Endomembrane → Axin|​S322_pho|​S326_pho|​S330_pho|​T609_pho|​S614_pho:​GSK3alpha/beta:​TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho@Endomembrane
7. IKK_beta|​pho:​TSC1:​TSC2@Endomembrane → IKK_beta|​pho:​TSC1|​S487_pho|​S511_pho:​TSC2@Endomembrane