Protein MKK1

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Modifications:
In compartment: cytosol

1. MKK1@cytosol
2. MKK1|​S218_pho|​S222_pho|​active@cytosol

Participates in complexes:
In compartment: cytosol

1. KSR1:​MKK1@cytosol
2. 14-3-3:​KSR1|​S392_pho:​MKK1@cytosol
3. KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
4. ERK1_br_ERK2:​KSR1:​MKK1:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
5. ERK1_br_ERK2:​KSR1:​MKK1|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
6. ERK1_br_ERK2:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
7. ERK1_br_ERK2|​T183_pho|​Y185_pho:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol

Participates in reactions:
As Reactant or Product:

1. MKK1@cytosol → MKK1|​S218_pho|​S222_pho|​active@cytosol
2. KSR1|​S392_pho@cytosol + 14-3-3@cytosol + MKK1@cytosol → 14-3-3:​KSR1|​S392_pho:​MKK1@cytosol
3. 14-3-3:​KSR1|​S392_pho:​MKK1@cytosol → KSR1:​MKK1@cytosol + 14-3-3@cytosol
4. ERK1_br_ERK2:​KSR1:​MKK1:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → ERK1_br_ERK2:​KSR1:​MKK1|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
5. ERK1_br_ERK2:​KSR1:​MKK1|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → ERK1_br_ERK2:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
6. ERK1_br_ERK2:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → ERK1_br_ERK2|​T183_pho|​Y185_pho:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
7. ERK1_br_ERK2|​T183_pho|​Y185_pho:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol + ERK1_br_ERK2|​T183_pho|​Y185_pho|​active@cytosol
8. Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho|​active@cytosol + ERK1_br_ERK2@cytosol + KSR1:​MKK1@cytosol → ERK1_br_ERK2:​KSR1:​MKK1:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol

As Catalyser:

1. ERK1_br_ERK2@cytosol → ERK1_br_ERK2|​T183_pho|​Y185_pho|​active@cytosol
2. ERK1_br_ERK2:​KSR1:​MKK1|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → ERK1_br_ERK2:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol
3. ERK1_br_ERK2:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol → ERK1_br_ERK2|​T183_pho|​Y185_pho:​KSR1:​MKK1|​S218_pho|​S222_pho|​S298_pho:​Raf-1|​S338_pho|​Y341_pho|​T491_pho|​S494_pho@cytosol