Protein FN1 map

Identifiers
HUGO:FN1

Maps_Modules
 MACROPHAGE  map
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
MODULE:INPUT_ACTIVATORS
MODULE:TUMOR_RECOGNTITON
MODULE:INTEGRINS
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1

References
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:24202395, PMID:22067905
Fibronectin plays important role in tumor microenviroment.
Primary tumors upregulate fibronectin
expression by resident fibroblasts in secondary organs.
Fibronectin (FN) controls the growth and survival of tumor cells. FN signaling is transmitted via integrins that eventually determine the cellular response to the changes in cell shape, mobility, and proliferation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FN1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. FN1@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. FN1@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FN1@TUMOR_CELL_AS_INDUCTOR map → map FN1@default map
  2. FN1@default map + ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map → map FN1:​ITGA5:​ITGB1@INNATE_IMMUNE_CELL_Membrane map
  3. rFN1@INNATE_IMMUNE_CELL_Cytosol map → map FN1@INNATE_IMMUNE_CELL_Cytosol map
  4. FN1@INNATE_IMMUNE_CELL_Cytosol map → map FN1@default map
  5. FN1@default map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  2. ZAP70@INNATE_IMMUNE_CELL_Cytosol map → map ZAP70|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. FYN@INNATE_IMMUNE_CELL_Cytosol map → map FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. PTK2@INNATE_IMMUNE_CELL_Cytosol map → map PTK2@INNATE_IMMUNE_CELL_Cytosol map