Identifiers
HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 GENECARDS:MAP2K2
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1
REACTOME:59505 KEGG:5605 ATLASONC:GC_MAP2K2 WIKI:MAP2K2
NATURAL_KILLER
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
CASCADE:TLR2_4
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK /ERK pathway, probably throught SYK
PMID:17395718, PMID:11062502, PMID: 15536084
PAK1 activates classical MEK/ERK cascad resulted in granule movement and polarization and tumor cel lysis downstream of Nkp30, Syk and PI3K.
PMID:10843677
IL2 activates MEK (MKK)/ERK pathway in NK cells.
MKK/ERK pathway is necessary for IL-2 to activate NK cells to express at least four known biological responses: LAK generation, IFN-gamma secretion, and CD25 and CD69 expression.
PMID:11034387
MAPK activation in NK cells resulted in lysis is Ras-independent.
PMID:22435554, PMID:15169888
In unstimulated cells, TPL-2 is confined to a cytoplasmic complex with
the NF-jB1 precursor protein p105, and the ubiquitin-binding protein ABIN-2.
Interactions with both p105 and ABIN-2 are required to maintain
TPL-2 protein stability, while TPL-2 association with p105 also inhibits TPL-2 phosphorylation of its substrates MEK-1⁄2