Protein HIF2A* map

Identifiers
HUGO:EPAS1

Maps_Modules
 MACROPHAGE  map
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
CASCADE:IL4
CASCADE:IL13
CASCADE:CSF2
CASCADE:IFNG

References
PMID:20194441
HIF2a expression is assosiated with M2 phenotype.
PMID:11888900, PMID:20644254
HIF2A induces tumor growth and angiogenesis.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia in vitro and by TAMs in hypoxic/necrotic areas of human tumors
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.
PMID:21765015, PMID:22869907
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production.
CSF2 upregulates expression of soluble form of VEGFR (sVEGFR-1) wich inhibits VEGF signaling via HIF2a. specific inhibition of PHD3 increases VEGF production.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HIF2A*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rHIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map HIF2A*@INNATE_IMMUNE_CELL_Cytosol map
    2. HIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map HIF2A*@INNATE_IMMUNE_CELL_Cytosol map
    3. HIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map degraded
    As Catalyser:
    1. rCSF1R@INNATE_IMMUNE_CELL_Cytosol map → map CSF1R@INNATE_IMMUNE_CELL_Cytosol map
    2. gFLT1@INNATE_IMMUNE_CELL_Cytosol map → map rtrVEGFR1*@INNATE_IMMUNE_CELL_Cytosol map
    3. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map → map rCXCR4@INNATE_IMMUNE_CELL_Cytosol map
    4. gFN1@INNATE_IMMUNE_CELL_Cytosol map → map rFN1@INNATE_IMMUNE_CELL_Cytosol map
    5. gCCR2@INNATE_IMMUNE_CELL_Cytosol map → map rCCR2@INNATE_IMMUNE_CELL_Cytosol map
    6. gCXCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL2@INNATE_IMMUNE_CELL_Cytosol map