Protein MICA map

Identifiers
HUGO:MICA

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
 NATURAL_KILLER  map
CASCADE:NKG2D
CASCADE:IL15
 DENDRITIC_CELL  map
CASCADE:IFNAB
PMID: 10426993, PMID: 11491531
NKG2D is an activating receptor that initiates NK and T cell–mediated cytotoxicity against transfectants and tumors expressing its ligands,‭ ‬MICA and MICB.‭

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MICA@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. MICA@TUMOR_CELL_AS_INDUCTOR map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. MICA@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MICA@INNATE_IMMUNE_CELL_Cytosol map → map MICA@TUMOR_CELL_AS_INDUCTOR_Membrane map
    2. MICA@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
    3. MICA@TUMOR_CELL_AS_INDUCTOR map → map MICA@TUMOR_CELL_AS_INDUCTOR_Membrane map
    4. rMICA@TUMOR_CELL_AS_INDUCTOR map → map MICA@TUMOR_CELL_AS_INDUCTOR map
    5. rMICA@INNATE_IMMUNE_CELL_Cytosol map → map MICA@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map