Protein GRB2 map

Identifiers
HUGO:GRB2

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:NK_ACTIVATING_RECEPTORS

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:NKG2D
CASCADE:IL4
CASCADE:Fc_gamma_RIII
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:16887996, PMID:16582911 
Vav1 interacts with DAP10 YxNM motifs through the adaptor protein Grb2 and is required for activation of PI3K-dependent Akt signaling.
binding of DAP10‭ ‬to either p85‭ ‬or Grb2‭ ‬alone is not sufficient to trigger DAP10-mediated cytotoxicity and that both binding sites are necessary for NKG2D-initiated killing.
PMID:10982827
Shc and GRB2 mediate Gab2 tyrosyl phosphorylation. Mutation of the three tyrosyl phosphorylation sites of Shc, which bind Grb2, blocks the ability of the Shc chimera to evoke Gab2 tyrosyl phosphorylation in B cells
PMID:8551221
SHC1 protein is phosphorylated upon CD16 and IL-2R Stimulation in Human NK Cells and interacts with GRB2

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GRB2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. GRB2:​LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. GRB2:​SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. GRB2@INNATE_IMMUNE_CELL_Cytosol map → map GRB2@INNATE_IMMUNE_CELL_Cytosol map
  2. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  3. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map + GRB2@INNATE_IMMUNE_CELL_Cytosol map → map GRB2:​LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. GRB2@INNATE_IMMUNE_CELL_Cytosol map + SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map GRB2:​SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. GAB2@INNATE_IMMUNE_CELL_Cytosol map → map GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11a*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  9. ITGB1@INNATE_IMMUNE_CELL_Membrane map + ITGA4@INNATE_IMMUNE_CELL_Membrane map → map (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane map
  10. SOS*@INNATE_IMMUNE_CELL_Cytosol map → map SOS*@INNATE_IMMUNE_CELL_Cytosol map