Protein S1PR* map

Identifiers
HUGO:S1PR1 HUGO:S1PR2 HUGO:S1PR3 HUGO:S1PR4 HUGO:S1PR5

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:DANGER_SIGNAL_PATHWAYS MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
 DENDRITIC_CELL  map
CASCADE:S1PR
PMID:11919175
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.
Immature and mature DC express the mRNA for different S1P receptors, such as endothelial differentiation gene (EDG)-1, EDG-3, EDG-5, and
EDG-6. In immature DC, S1P stimulated pertussis toxin-sensitive Ca2+ increase actin polymerization and chemotaxis. These responses were lost by DC matured with
lipopolysaccharide. In maturing DC, however, S1P inhibited the secretion of tumor necrosis

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. S1PR*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  2. Sphingosine 1-phosphate@TUMOR_CELL_AS_INDUCTOR map + S1PR*@INNATE_IMMUNE_CELL_Membrane map → map S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: