Simple molecule O_sub_2_endsub_ map
O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Identifiers
CHEBI:15379, KEGGCOMPOUND:C00007, CAS:7782-44-7

Maps_Modules
 DENDRITIC_CELL  map
MODULE:IMMUNE_STIMULATION
MODULE:ANTIGEN_PRESENTATION
MODULE:EFFECTOR_ACTIVATION

References
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.

O_sub_2_endsub_@TUMOR_CELL_AS_INDUCTOR_Membrane

References
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.

O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
 MACROPHAGE  map
 MDSC  map
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:S100A

References
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:18809714, PMID:12645005
S100A9 regulates myeloid cell differentiation via reactive oxygen species (ROS), probabli via NAPDH oxidase.
S100A9 may suppress myeloid cell differentiation via persistent up-regulation of ROS in progenitor cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. O_sub_2_endsub_@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    2. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
    3. L-arginine@INNATE_IMMUNE_CELL_Cytosol map + O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map + NADPH@INNATE_IMMUNE_CELL_Cytosol map → map NO@INNATE_IMMUNE_CELL_Cytosol map + L-citrulin@INNATE_IMMUNE_CELL_Cytosol map + NADP+@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane map → map oxPS@default map