Simple molecule O_sub_2_endsub__super_-_endsuper_ map
O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane

Identifiers
CHEBI:18421, KEGGCOMPOUND:C00704, CAS:11062-77-4

Maps_Modules
 DENDRITIC_CELL  map
MODULE:IMMUNE_STIMULATION
MODULE:ANTIGEN_PRESENTATION
MODULE:EFFECTOR_ACTIVATION

References
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.

O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
 NEUTROPHIL  map
 MACROPHAGE  map
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:NO_ROS_PRODUCTION
CASCADE:TGFB

References
PMID:19372727
The enzyme responsible for O2•- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:19732719
Inhibition of TGF-ß signaling in vivo increases CD11b+ cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide  and H2O2 production) in neutrophils

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map H_sub_2_endsub_O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    2. O_sub_2_endsub_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map O_sub_2_endsub__super_-_endsuper_@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    3. O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map → map O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map
    4. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map → map ROS_production@default map
    5. O_sub_2_endsub__super_-_endsuper_@INNATE_IMMUNE_CELL_Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: