Protein CFL1 map

Identifiers
HUGO:CFL1

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 NATURAL_KILLER  map
PMID:11698448
LIMK1 is a serine/threonine kinase that phosphorylates and inactivates the actin-depolymerization factor cofilin, thereby regulating actin cytoskeletal reorganization.
LIMK1 phosphorylates CLF1 (cofilin) downstream of killer cell-activating receptors via RHOA/ROCK1 pathway.
Inhibition of the p160ROCK/LIMK1 pathway results in decreased actin polymerization at the effector/target interface.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CFL1@INNATE_IMMUNE_CELL_Cytosol map
  2. CFL1|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CFL1@INNATE_IMMUNE_CELL_Cytosol map → map CFL1|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map