Identifiers
HUGO:CDC42
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
NATURAL_KILLER
PMID:17785506
TRIP10 (CIP4) functions downstream of Cdc42 to induce MTOC polarization to the IS and cytotoxicity.
PMID:16329184
VAV1 and VAV2 proteins can activate cdc42
PMID:15001467
CD16 signaling activates cdc24 in NK cells probably via vav proteins.
PMID:22126964
Cdc42 activation is downstream of PI3K pathway (probably via VAVs)
PMID:15169870
Cdc42 activation was restricted to the leading margin of the cell, whereas Rac1 was active throughout the phagocytic cup. During phagosome closure, activation of Rac1 and Rac2 increased uniformly and transiently in the actin-poor region of phagosomal membrane. These distinct roles for Cdc42, Rac1, and Rac2 in the component activities of phagocytosis indicate mechanisms by which their differential regulation coordinates rearrangements of actin and membranes.
PMID:9831565, PMID:19741094
Inactivation of Cdc42, either by expression of a dominant-negative mutant or by knockdown, greatly inhibits phagocytosis
PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.