Protein WASP* map

Identifiers
HUGO:WAS

Maps_Modules
MODULE:TUMOR_KILLING MODULE:EFFECTOR_ACTIVATION MODULE:EXOCYTOSIS_AND_PHAGOCYTOSIS

References
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:CR3
CASCADE:Fc_gamma_RII
CASCADE:KIR2DL1
PMID:15001467, PMID:14707117
CD16 or ITGB2 (CD18) stimulation resulted in the induction of WASp tyrosine phosphorylation in NK cells,
probubly by Fyn. Fyn enhanced WASp-mediated Arp2/3 activation and was required for synapse formation in T cells.
PMID:12177428
NK cell cytotoxicity was deficient in WAS patients and WASp catalyzes actin polymerization.
It binds actin monomers as well as the actin-related protein (ARP) 2/3 complex to catalyze branching of filamentous actin (F-actin)
PMID:16606694
WIPF1 forms complex with WASP.
PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.
Cdc42 Is Required for Activation and Tyrosine Phosphorylation of WASP/N-WASP
PMID:11395419
Arp2/3 complex is intrinsically inactive, relying on nucleation promoting factors for activation. WASp/Scar family proteins are prominent cellular nucleation promoting factors. They bring together an actin monomer and Arp2/3 complex in solution or on the side of an existing actin filament to initiate a new filament that grows in the barbed end direction.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. WASP*@INNATE_IMMUNE_CELL_Cytosol map
  2. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map
  2. TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. WASP*@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TRIP10@INNATE_IMMUNE_CELL_Cytosol map → map TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map → map MTOC_polarization@INNATE_IMMUNE_CELL_Cytosol map