Complex STAT1:TNFR1* map
Complex composition:

  1. STAT1 map
  2. TNFR1* map

STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:STAT1:TNFR1*

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS

References
 MACROPHAGE  map
PMID:22435554, PMID:15169888
In unstimulated cells, TPL-2 is confined to a cytoplasmic complex with
the NF-jB1 precursor protein p105, and the ubiquitin-binding protein ABIN-2.
Interactions with both p105 and ABIN-2 are required to maintain
TPL-2 protein stability, while TPL-2 association with p105 also inhibits TPL-2 phosphorylation of its substrates MEK-1⁄2
PMID:22435554, PMID:15485931, PMID:21217011, PMID:15199157
Agonist stimulation induces IKK2, a catalytic subunit of the IKK complex, to phosphorylate p105. These phosphorylations
create a binding site for the ubiquitin E3 ligase complex SCF-bTrCP which catalyzes K48-linked polyubiquitination of p105, followed by its proteasomal
degradatio. This releases TPL-2 from p105 inhibition and allows TPL-2 to access its substrate MEK ()

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TNFR1*@INNATE_IMMUNE_CELL_Membrane map → map STAT1|​pho:​TNFR1*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: