References
PMID:21115385, PMID:10433356
IL10‭ ‬acts via IL10‭ ‬receptor.
IL10‭ ‬first binds to IL10RA
The IL10/IL10R1A ‬interaction changes the cytokine
conformation allowing the association of
the IL10/IL10RA ‬complex with IL10RB.
PMID:‭15833879
‭Anti IL-10 receptor–specific antibody
switched TAMs from an M2 to an M1
macrophage–like phenotype.