Identifiers
HUGO:IL10

Maps_Modules
 MACROPHAGE 
 MDSC 
 DENDRITIC_CELL 
 NATURAL_KILLER 
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
CASCADE:IL10
CASCADE:TGFB
CASCADE:MIF
CASCADE:CSF1
CASCADE:IL12
CASCADE:STING
CASCADE:TLR2_4
CASCADE:IFNAB
CASCADE:FLT3LG
CASCADE:IFNG
CASCADE:IL4

References
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10‭ ‬ expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:10542212
IL10‭ ‬ promotes M2‭ ‬phenotype of macrophages
trough suppression of‭ ‬NFkB signaling
and inhibition of synthesis of pro-inflammatory cytokines.
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation.
PMID:16713974, PMID:14607900
IL10 and Stat3 mediate feedback inhibition of TLR signaling. TLR2/TLR4 induces
IL10 expression. IL10 inhibits exppression of TNF downstream of TLR.
PMID:16713974
Production of IL10 is partially ERK dependent.
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
At the same tyme IL10 siglaning also participates in ID3 upregulation via PI3K/AKT pathway
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
PMID:9834059
NK cells stimulated by IL12 induces IL10 production.
PMID:11207245
IFNA induces IL10 production in Dcs (negative loop)
PMID:21220452
that IL-10 increased March1 mRNA by approximately six fold
PMID:15579430
Metastatic Melanoma Secreted IL-10 Down-Regulates CD1(CD1a, CD1b, CD1c, and CD1d) protein Molecules on Dendritic Cells in Metastatic Tumor Lesions (
PMID:16424049
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC

1. IL10@INNATE_IMMUNE_CELL_Cytosol

1. IL10@default

1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane
2. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol → IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
2. IL10@INNATE_IMMUNE_CELL_Cytosol → IMMUNE_SUPRESSION@default
3. IL10@default + IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane → IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane
4. rIL10@INNATE_IMMUNE_CELL_Cytosol → IL10@INNATE_IMMUNE_CELL_Cytosol
5. IL10@INNATE_IMMUNE_CELL_Cytosol → IL10@default

1. JAK1@INNATE_IMMUNE_CELL_Cytosol → JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol
2. TYK2@INNATE_IMMUNE_CELL_Cytosol → TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol
3. gID3@INNATE_IMMUNE_CELL_Cytosol → rID3@INNATE_IMMUNE_CELL_Cytosol
4. THBS1@INNATE_IMMUNE_CELL_Cytosol → THBS1@default
5. gCD163@MARKERS_MACROPHAGE → rCD163@MARKERS_MACROPHAGE
6. ICAM1@INNATE_IMMUNE_CELL_Cytosol → ICAM1@INNATE_IMMUNE_CELL_Membrane
7. gMARCH1@INNATE_IMMUNE_CELL_Cytosol → rMARCH1@INNATE_IMMUNE_CELL_Cytosol
8. gDUSP1@INNATE_IMMUNE_CELL_Cytosol → rDUSP1@INNATE_IMMUNE_CELL_Cytosol
9. CD80@INNATE_IMMUNE_CELL_Cytosol → CD80@INNATE_IMMUNE_CELL_Membrane
10. STAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
11. gARG2@INNATE_IMMUNE_CELL_Cytosol → rARG2@INNATE_IMMUNE_CELL_Cytosol
12. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol → rMHC class II*@INNATE_IMMUNE_CELL_Cytosol
13. rCD1*@INNATE_IMMUNE_CELL_Cytosol → CD1*@INNATE_IMMUNE_CELL_Cytosol
14. gNFKBID@INNATE_IMMUNE_CELL_Cytosol → rNFKBID@INNATE_IMMUNE_CELL_Cytosol
15. gTNIP3@INNATE_IMMUNE_CELL_Cytosol → rTNIP3@INNATE_IMMUNE_CELL_Cytosol
16. p38*@INNATE_IMMUNE_CELL_Cytosol → p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol