Complex IL10:IL10RA:IL10RB map
Complex composition:

  1. IL10RB map
  2. IL10 map
  3. IL10RA map

IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL10:IL10RA:IL10RB

Maps_Modules
 MACROPHAGE  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL10

References
PMID:21115385, PMID:10433356
IL10‭ ‬acts via IL10‭ ‬receptor.
IL10‭ ‬first binds to IL10RA
The IL10/IL10R1A ‬interaction changes the cytokine
conformation allowing the association of
the IL10/IL10RA ‬complex with IL10RB.
PMID:‭15833879
‭Anti IL-10 receptor–specific antibody
switched TAMs from an M2 to an M1
macrophage–like phenotype.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL10@default map + IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map → map IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map