Gene TGFB1 map

Identifiers
HUGO:TGFB1

Maps_Modules
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:EFFECTOR_INHIBITION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_EXPRESSION
 MACROPHAGE  map
 MDSC  map
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
CASCADE:TGFB
CASCADE:STING
CASCADE:IL4
CASCADE:IL13
CASCADE:TNF
CASCADE:TLR2_4

References
PMID:16327802
IL13 and TNF inducese TGFB1 expression via AP-1 transcription factors.IL13 induces binding of c-jun and fra2 ti TGFB1 promotor, and TNF binding of c-jun, JunD and c-fos.
PMID:21372296
HMGB1 markedly increased the expression of the genes for VEGF, and TGFB1 in
peritoneal macrophages.
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGFβ, VEGF.
PMID:24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-α
ARG1, TGFB, COX2 expression is downregulated in IL4R-/- MDSC (probably via STAT3 and MYC).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTGFB1@INNATE_IMMUNE_CELL_Cytosol map → map rTGFB1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: