RNA TNF map

Identifiers
HUGO:TNF

Maps_Modules
 MACROPHAGE  map
 MDSC  map
 NEUTROPHIL  map
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
MODULE:TUMOR_KILLING
MODULE:EFFECTOR_ACTIVATION
MODULE:APOPTOSIS_INDUCING_LIGANDS
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
CASCADE:TGFB
CASCADE:MIF
CASCADE:Fc_gamma_RIII
CASCADE:TLR2_4
CASCADE:CSF2
CASCADE:CSF1
CASCADE:IFNG
PMID:19732719 
Inhibition of TGF-ß signaling downregulates Arginase1, CCL5 and CCL2 expression and upregulates TNF, ICAM1,CCL3 expression (mRNA) in tumor neutrophiles (TAN)

References
PMID:1431106
TNF is ploinfammatory cytokine induced
tumoricidal activity of macrophages
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rTNF@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
    2. rTNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: