Identifiers
HUGO:MMP9
Maps_Modules
MACROPHAGE
MDSC
MAST_CELL
MODULE:EFFECTOR_INHIBITION
MODULE:TUMOR_GROWTH
MODULE:ANGIOGENIC_FACTORS
MODULE:MATRIX_REMODELLING
CASCADE:MIF
CASCADE:IL10
CASCADE:IL4
CASCADE:IFNAB
NEUTROPHIL
References
PMID:11875494
MMPs plays important in the degradation and remodeling of the
extracellular matrix at sites of inflammation. HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:18633355
MMP7, MMP9 and MMP12 from macrophages drives angiogenesis
MDSC isolated from murine tumours express higher levels of various MMPs (MMP2, MMP9, MMP13 and MMP14 than MDSC from healthy mice
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:21896641
mast cells and mast
cell derived MMP-9 contribute to the development of
well-differentiated prostate tumors
PMID:22425643
A key mediator secreted from neutrophils and involved in carcinogenesis
is MMP-9. It was demonstrated to be involved in skin tumorigenesis,
by regulation of oncogene-induced keratinocyte hyperproliferation
and their progression to invasive cancer (71). In addition to its effects
on matrix, it has been shown that MMP-9 secreted from neutrophils
(among other bone marrow cells) prevents apoptosis of tumor cells in
the lung (72).
→ MATRIX_REMODELLING@default
→ ANGIOGENESIS@default
→ MMP9@INNATE_IMMUNE_CELL_Cytosol