Identifiers
HUGO:TNIP3
MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
CASCADE:IL10
References
PMID:17485448
TNIP3 (ABIN3) inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream NFkB signaling downstream of IL10.