Identifiers
HUGO:BCL3
Maps_Modules
MACROPHAGE
CASCADE:IL10
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE
References
PMID:15465827
BCL3 inhibits expression of IL1A, IL1B,TNF and positively regulates
IL-10 expression. BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
PMID:12907458
Bcl-3 interacted with NF-κB p50,
both Bcl-3 and p50 were recruited to the TNF promoter,
BCL3 and p50 NFkB recruitment to TNF promoter
prevents binding of p65/p50 NFkB heterodimers
to TNF promotor and suppresses TNF expression
downstream of IL10.
NFkB p50 is needfull for BCL3 expression .
PMID:12907458, PMID:22323479
STAT3 directly up-regulates BCL3 expression downstream of IL10 .