Gene SOCS3 map

Identifiers
HUGO:SOCS3

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:TNF
CASCADE:CSF2

References
PMID:12754507, PMID:24418198
SOCS3 binds with high affinity to the phosphorylated Tyr759 (Y759)
Of gp130 to suppress IL-6 signaling.
PMID:12907458, PMID:16713974
IL10 induces SOCS3 expression in STAT3 dependent manner.
SOCS3 binds to gp130 and inhibits inflammatory IL6 signaling in macrophages. Probabaly downstream of IL10
PMID:14764699
SOCS1 and SOCS3 are upregulated in mature DC. SOCS2 in immature DC.
SOCS1 and SOCS2 expression is induced by IL4 signaling, and SOCS3 expression is upregulated more by GM-CSF (CSF2).

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: