RNA SOCS3 map

Identifiers
HUGO:SOCS3

Maps_Modules
 MACROPHAGE  map
 DENDRITIC_CELL  map
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:TNF
CASCADE:CSF2

References
PMID:12754507, PMID:24418198
SOCS3 binds with high affinity to the phosphorylated Tyr759 (Y759)
Of gp130 to suppress IL-6 signaling.
PMID:12907458
IL10 induces SOCS3 expression in STAT3 dependent manner.
PMID:10606755
LPS and TNFalpha were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNF-alpha.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
    2. rSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map SOCS3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: