Identifiers
HUGO:IFNG
Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
References
MACROPHAGE
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:TGFB
CASCADE:IL4
CASCADE:Fc_gamma_RIII
CASCADE:IL18
CASCADE:IL12
CASCADE:IL2
CASCADE:IL15
PMID:25582338
IL15 induces IFNG expression in DC via STAT3.
PMID:24829413
STAT5 is phosphorylated downstream IL2, It upregulate the promoter activity of both IL2RA and IFNG in dendritic cells downstream of IL2
PMID:12413632
IFNG is a major factor of M1 activation of macrophages
PMID:8700208, PMID:9715265, PMID:11449378, PMID:8683106
STAT4 induces IFNG production via binding of Stat4 to IFNG promoter GAS element downstream of IL12 in NK.
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB in NK. TGFB signaling could target IFNG gene expression via TBX21 (TBET) and in a SMAD-dependent fashion that is independent of T-BET. SMAD3 can directly interact with IFNG promoter in NK cells
PMID:7650486, PMID:9973469, PMID:9374532
NF-AT, migrates to the nucleus and activates transcription of cytokines TNF, GM-CSF , IL-2, IL-4. Fas ligand ( FasL ) and, possibly, IFNG.