Identifiers
HUGO:IFNG
Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS MODULE:EFFECTOR_ACTIVATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
References
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:TGFB
CASCADE:IL4
CASCADE:KLRB1
CASCADE:IL12
CASCADE:IL15
CASCADE:Fc_gamma_RIII
CASCADE:IL18
PMID:8700208, PMID:9715265, PMID:11449378
IL-12 signaling induces STAT4 tyrosine phosphorylation. And induces IFNG production via binding of Stat4 to IFNG promoter GAS element.
PMID:11801649, PMID:11449378
IL 12and IL-18 synergistically enhance IFN-gamma production in human NK cells.
IL-12-activated STAT4 interacts with c-Jun to form a protein-protein complex.
c-Jun induced by IL-12 plus IL-18 exhibits a markedly enhanced AP-1-binding activity
and induces INFG promoter.
PMID:12759422
IL-18 induces NF-κB binding to the IFN-γ gene promoter and induction of gene expression.
IL-15 activated the binding of STAT1, STAT3, STAT4, and STAT5 to the regulatory sites of the IFNG gene.
PMID:18768831, PMID:16713975
TGF-β inhibits NK cell IFN-γ and TNF-α production following CD16 activation.
TGF-β signaling could target IFNG gene expression via TBX21 (TBET) and in a SMAD-dependent fashion that is independent of T-BET.
SMAD3 can directly interact with IFNG promoter.
+ IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG:MIR15/16*@INNATE_IMMUNE_CELL_Cytosol
→ degraded
→ rIFNG@INNATE_IMMUNE_CELL_Cytosol
→ IFNG@INNATE_IMMUNE_CELL_Cytosol