Gene TUMOR_DNA map

Maps_Modules
 DENDRITIC_CELL  map
MODULE:INPUT_ACTIVATORS
MODULE:TUMOR_RECOGNTITON
MODULE:DANGER_SIGNAL_PATHWAYS
CASCADE:STING

References
PMID:25517615, PMID:25517609, PMID:24766893
DNA from dying cells activates cGAS to form a dimeric cGAS-DNA complex which synthesizes 2′3′-cGAMP from ATP and GTP. cGAMP binds to STING and activates two pathways, NfkB activation (via IKK activation) and IRF3 via TBK1 activation. IRF3 induces IFNB expression in DC downsteam of STING signaling
PMID:24799564, PMID:15967784, PMID:16237046, PMID:2398653
But at the same time STING signaling induces IDO activation (production) probably via IFN I/STAT1 pathway and suppress local immunity.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gTUMOR_DNA@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. gTUMOR_DNA@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TUMOR_DNA:​cGAS*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gTUMOR_DNA@INNATE_IMMUNE_CELL_Cytosol map + cGAS*@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_DNA:​cGAS*@INNATE_IMMUNE_CELL_Cytosol map
  2. gTUMOR_DNA@TUMOR_CELL_AS_INDUCTOR_Membrane map → map gTUMOR_DNA@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. ATP@INNATE_IMMUNE_CELL_Cytosol map → map cGAMP@INNATE_IMMUNE_CELL_Cytosol map