Protein _beta_-Catenin* map

Identifiers
HUGO:CTNNB1

Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:MIRNA_TF_IMMUNOSUPPRESSIVE

References
 DENDRITIC_CELL  map
CASCADE:CATENINB
PMID:24023259
β-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells
PMID:25730849
L-10 Mediates β-Catenin–Dependent Inhibition of Cross-Priming,β-catenin enhanced IL-10 induction through mTOR pathway.
β-Catenin up-regulates level of mTOR in DCs and activates mTOR signaling.
PMID:20705860
β-catenin signaling in DCs is required to induce Treg cells and suppress TH1/TH17 responses.
β-catenin signaling in intestinal DCs promotes the expression of Raldh and suppresses the expression of proinflammatory cytokines (IL6, IL23a,IL12p40)
but induces IL10 production.
PMID:15001769, PMID:17936032
GSK3B phosphorylates beta-catenin and inhibits its activity.
Beta-catenin signaling prevents production of inflammatory cytokines IL6, IL-1α, IL-6, TNF-α, and IL-12 p40,
But upregulates CCR7, both at the mRNA level and on the plasma membrane.
CCR7 is a chemokine receptor important for the migration of DCs from the periphery to T cell areas of lymph nodes.
DCs matured by CD activation of beta-catenin signaling alone failed to prime CD4 T cells to produce IFN-γ but did generate high levels of IL10 (Fig. 6A) together with other cytokines (not shown) consistent with type I regulatory T cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map
  2. _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map → map _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  3. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map → map _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map + E-Cadherin*@INNATE_IMMUNE_CELL_Cytosol map + _alpha_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. DEPTOR:​MLST8:​ORP1L*:​PRAS40*:​RILP@INNATE_IMMUNE_CELL_Cytosol map → map (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. gCCR7@INNATE_IMMUNE_CELL_Cytosol map → map rCCR7@INNATE_IMMUNE_CELL_Cytosol map