Identifiers
NAME:DEPTOR:MLST8:MTOR:PRAS40*:RPTOR
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:IL15
CASCADE:CSF2
24973821, 24795729
High level of IL15 activates mTOR. mTOR controls production of GZMA and GZMB and IFNG production downstream of IL15
16469695, 26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
22504639, 20805416
Impaired mTORC1 signal resulted in the suppression of IL-10 production in DC.
IL-10 expression was impaired at both protein and mRNA levels in RaptorDC−/− mice.
19143636
The signalling function of mTOR complex 1 is activated by Rheb-GTP.
20805416
mTOR pathway plays divergent roles during activation and differentiation of myeloid DCs (MDSC) and monocyte-derived DCs (moDCs). Inhibition of mTORC1 in MDSC activated with TLR-dependent or -independent stimuli increased proinflammatory cytokines and NF-κB, whereas IL-10 and STAT3 were blocked. Rapamycin regulated the costimulatory/surface molecules CD86, programmed death ligand-1, and CD25 on MDSC and significantly increased the T cell allostimulatory potential of MDSC. In contrast, rapamycin suppressed immunostimulatory molecules and the allostimulatory potential of LPS-stimulated moDCs by an inability to augment NF-κB signaling. In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF to induce DC differentiation in an mTORC1-dependent manner.
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.
Identifiers
NAME:DEPTOR:MLST8:ORP1L*:PRAS40*:RILP
Maps_Modules
MODULE:CORE_SIGNALING_PATHWAYS MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
NATURAL_KILLER
16469695, 26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
22504639, 20805416
Impaired mTORC1 signal resulted in the suppression of IL-10 production in DC.
IL-10 expression was impaired at both protein and mRNA levels in RaptorDC−/− mice.
19143636
The signalling function of mTOR complex 1 is activated by Rheb-GTP.
20805416
mTOR pathway plays divergent roles during activation and differentiation of myeloid DCs (MDSC) and monocyte-derived DCs (moDCs). Inhibition of mTORC1 in MDSC activated with TLR-dependent or -independent stimuli increased proinflammatory cytokines and NF-κB, whereas IL-10 and STAT3 were blocked. Rapamycin regulated the costimulatory/surface molecules CD86, programmed death ligand-1, and CD25 on MDSC and significantly increased the T cell allostimulatory potential of MDSC. In contrast, rapamycin suppressed immunostimulatory molecules and the allostimulatory potential of LPS-stimulated moDCs by an inability to augment NF-κB signaling. In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF to induce DC differentiation in an mTORC1-dependent manner.