Protein HSP70* map

Identifiers
HUGO:HSPA1A

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:IMMUNE_STIMULATION MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
CASCADE:TLR2_4
PMID:25103413
Hypoxia downregulates HSP70 level in membrane.
PMID:20093776
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. HSP70*@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. HSP70*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HSP70*@TUMOR_CELL_AS_INDUCTOR map → map HSP70*@default map
    As Catalyser:
    1. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map