Protein MYD88 map

Identifiers
HUGO:MYD88

Maps_Modules
 DENDRITIC_CELL  map
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:IL18
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
CASCADE:TLR2_4
CASCADE:IFNG
CASCADE:IL15

References
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.
PMID:23811849
HMGB1 is a nuclear nonhistone chromatin-binding protein. It is secreted at the late stages of cellular demise and iactivates TLR4/MyD88 pathway in dendritic cells (DCs) to accelerate the processing of phagocytic cargo in the DC and to facilitate antigen presentation by DC to T cells.
PMID:17704786
DCs require signaling through TLR4 and its adaptor MyD88 for efficient processing and cross-presentation of antigen from dying tumor cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. MYD88@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  2. CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  3. IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  4. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  2. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  3. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  4. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  5. rMYD88@INNATE_IMMUNE_CELL_Cytosol map → map MYD88@INNATE_IMMUNE_CELL_Membrane map
  6. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  2. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  3. TGFB*@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@default map
  4. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  5. VEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@default map
  6. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
  7. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  8. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
  9. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
  10. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  11. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  12. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  13. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
  14. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  15. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  16. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map