Complex ITGAV:ITGB5 map
Complex composition:

  1. ITGB5 map
  2. ITGAV map

ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:ITGAV:ITGB5

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:INTEGRINS MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB5
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
Cross-present Antigens to Cytotoxic T Lymphocytes.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map → map ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: