Complex ITGAV:ITGB5:MFGE8 map
Complex composition:

  1. MFGE8 map
  2. ITGAV map
  3. ITGB5 map

ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:ITGAV:ITGB5:MFGE8

Maps_Modules
MODULE:INPUT_ACTIVATORS MODULE:TUMOR_RECOGNTITON MODULE:INTEGRINS MODULE:DANGER_SIGNAL_PATHWAYS

References
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB5
PMID:14697347, PMID:11146654
Integrin αvβ5 regulates phagocytosis via CRK /DOCK1 (DOCK180) /RAC1 pathway downstream of.
Integrin αvβ5 activation results in recruitment of the p130cas–CrkII–Dock180 complex and RAC1 activation.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map → map ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map